بررسي تغييرات برخي از شاخص هاي متابوليسم استخوان در بيماران تحت درمان با هورمون هاي تيروييد

Study of Some Variations in Bone Metabolism Indices in Patients Under Thyroid Hormones Treatment

This study was conducted to study bone metabolism indices such as Calcium , Phosphorus and Alkalen phosphatase in 26 patients ; 23 of them received 100-200 mg/day levothyronine and 3 received levothyronine 50 mg/day . 17 patients with simple goiter (14 F , 3 m) , 3 patients with benign thyroid (all female) and 6 patients (2 F , 4 m) with primary hypothyroidity were under treatment with thyroid hormones for 6 to 24 months . 5 patients were under 17 years of age , 13 patients from 17 to 40 years and 8 of them over 40 . Patients of each group were divided into two groups ; (a) patients with subclinical hyperthyroidity due to the treatmaut and (b) patients with normal FTI , T3 RU , T3 and T4 , fter taking the hormones . A homogeneous control group including 45 subjects with confirmed health were also ʹselected The statistical analysis revealed no significant difference between the cases and controls . However , the comparison of the mean Alkalen phosphatase concentration revealed that there was a, significant increase in 17-40-year subjects ofthe first group ; while , the difference seemed insignificant amog other age groups . It was concluded that thyroid hormones caused subclinical hyperthyroidity , bone metabolism was affected , bone mass decreased leading to the risk of bone fracture with a little pressure .