تاثير پركاري تيروييد بر روي هورمون هاي بخش قشري غدد فوق كليه

The Effect of Hyperthyroidism on Adrenal Cortex Hormones

Background and Objectives: The most important body control systems are endocrine glands which have ability to regulate cell functions by different ways. Multiple factors can affect this regulation, such as effects of endocrine hormones on each other. In this study, we evaluate effects of thyroid hormones on adrenal cortex secretion. Urine 17-OHKS as glucocorticoid metabolic, and urine i7-CS as androgen metabolite, were measured. Materials and Methods: This study was done on 100 healthy volunteers and results compared with 100 hyperthyroid patients. T3, T4, TSH, 17-Ketosteroids and 17-OH steroids were measured. There. was a positive correlation between T3 and T4 and urine 17-KS in patients with hyperthyroidism (r=0.64-0.72) and a negative correlation between TSH and urine 17-KS (r=0.74). Results: Urine 17-OHKS levels in healthy volunteers were 2-9.6 p.g/mg creatininc (mean 5.4±1.87) and in hyperthyroid patients was 9.2-17Ftg/mg creatininc, (mean 12.5±3.2) (p<0.01). Urine 17-KS levels in healthy volunteers were 1.5-15Erg/mg creatininc (mean 5.85±2.1) and in hyperthyroid patients were 15.1-23 (mean 17.9±2.87) (p<0.01). In statistical analysis by rcggretion line method in these two endocrine glands hormones, there was a positive correlation between T3 and 17-OHKS (r = 0.72) and T3 and 17-KS (r=0.74) and a negative correlation between TSH with 17-OI-IKS and 17-KS (r=0.74). However there were not any correlation betwenn T4 with 17-OHKS and 17-KS in healthy volunteers. Conclusion: These results indicated that increase of thyroid hormones have some effects on adrenal cortex secretion, which may suggest different ways for treatment of adrenal cortex secretion disorders.