فروكتوزآمين ، كنترل ديابت و ارايه يك مدل جديد

FRUCTOSAMIN AND CONTROL OF DIABETES AN INTRODUCTION OF A NEW MODEL

The major aim of all therapeutic programs in diabetes mellitus is maintenance of blood glucose level in normal range. At present, in achieving this porpuse, measurment of fasting blood sugar (FBS) and glycosilated hemoglobin Al (HbA1) are commonly used as glycemic control indices. Since the above two tests cannot depict the metabolic state of the patient under all conditions, thus this study was conducted with the aim to control diabetic patients by determining serum fructosamin levels allowing a direct surveillance over the mean blood sugar levels during tine intervals when assessnent of it with other indices was not feasible. Serum fructosamin was evaluated in 90 diabetic patients not adequately controlled (Typel, II). for 3 times with an interval of 2 weeks and in 100 normal samples as a medium index glycemic control. The method is colorimetric on the base of nitroblue tetrazulium reduction. According to the results serum fructosamin in comparison HbA1 is a sensitive parameter to show fluctuation of blood glucose, furthermore some agents such as age, sex, chronic disease, hematolgic disease and drug consumption dont effect the serum fructosamin level. In this study direct estimation of mean blood glucose at 1-3 past week with application of multiple regression analysis, provided a diagram allowing monitoring blood glucose on the base of fructosamin concentration. By this method, in uncontrolled diabetic patients, using the above model and assessment of serum frucfosamin levels, the course of treatment and improvement secondary to blood glucose control with the initiation of treatment and changes in treatment can be easily assessed and controlled. So, for assurance to do effective treatment, fructosamin in comparison with other glycemic parameter, has peculiar importance.