مروري بر نقش ويروس هرپس در بيماريهاي پريودنتال

A review on the role of herpes virus on periodontal diseases

Background and Aim: Periodontitis encompasses a variety of infectious entities with various unique microbial and immune responses. Findings within the last decade have provided initial evidence that human herpes viruse contributes to the periodontal disease development. This investigation studies the presence of herpes viruses in periodontal pockets and the corresponding gingival tissue from periodontally healthy and periodontitis sites. Methods and Materials: A nested - polymerase chain reaction was employed to identify the presence of HCMV, EBVI, EBV2, herpes simplex virus, human herpes virus HHV-6, HHV-7, HH-8 in each test sample. Results: Epstein - Barr virus type 1 (EBV-1), human cytomegalovirus (HCMV) and T-lymphocytes are seen more frequently in periodontal lesions and acute necrotizing ulcerative gingivitis. It was also noted than periodontic lesions harbor elevated levels of bacterias including Actinobacillus Actinomycetemcomitans, Porphycomonas gingivals, Bacteriodes forsythus, Prevotella intermedia, Prevotella nigreseens and Treponema denticola. Conclusion: The role of certain herpes viruses are clearly seen in the etiology and pathogenesis of human periodontal disease. Vaccination against herpes viruses could be considered as an important approach in periodontal prophylaxis and treatment.