بررسي اثرات هيستوپاتولوژيكي عصاره سيري داخل صفاقي بر كبد موش صحرايي

A Histopathological Study of Effects of Intraperitoneal Garlic Extract on Liver in Rats

In recent years, many investigations have reported the pharmaceutical effects of garlic such as antibacterial, antihypertension, antithrombotic, anticarcinogenic and many others. Studies suggest that garlic may has toxic effects on body tissues. In this study, histopathological effects of garlic extract on liver tissue in rats were investigated. The animals were divided into five groups including control group (received saline) and four experimental groups (received garlic extract, 50, 100, 200 and 400mg/kg intraperitonally for a month). The sections of liver tissue were stained by H&E method for histopathological examination. The histopathological examination indicated that administration of low dose of garlic (50mg/Kg) has little effects on liver tissue in comparison with the control animals. However, administration of high dose of garlic (400mg/kg) induce considerable damage on this tissue in comparison to other groups. Although the use of garlic is useful for body, the consumption of high levels of garlic may induce toxic effects on body tissues. Therefore, further studies are needed before garlic preparations can be used as medicine.