بررسي اتيولوژي و خصوصيات باليني و آزمايشگاهي در 47 بيمار مبتلا به ضايعه لينكوييد مخاط دهان

Etiology, clinical and laboratory findings in patients with oral lichenoid lesions

Aim: The purpose of this study was to evaluate the frequency of idiopathic lichen planus among a group of patients with oral lichenoid changes. Method and Materials: A group of 47 patients with oral lichenoid lesions were evaluated in the department of oral medicine, Kerman dental school. Diagnosis of lichenoid tissue changes was confirmed by histologic examination of tissue biopsies in all cases. Carbohydrate metabolism status and liver function tests were evaluated in all patients. The diagnosis of idiopathic lichen planus was suggested after other causes of lichenoid tissue reactions had been ruled out. Statistical analysis was performed using a X` and t - test. Results: The mean age of the study group was 41 years. Oral lichenoid lesions were somewhat more common in females than males of this population (55,3% vs 44.7%). The buccal mucosa and tongue were the most common sites of involvement. The present study showed that idiopatic lichen planus was the cause of oral lesions about in 87.2% of patients. Contact reaction to amalgam restorations was the second common cause of oral lichenoid lesions. Laboratory evaluation showed that 19.4% of lichen planus patients suffered from impaired glucose metabolism. Intrestingly, diabetes mellitus was also reported in 12.9% of lichen planus patients. Conclusion: This study suggests that oral lichenoid lesions are heterogenous, despite of their clinical and histological similarities and idiopathic lichen planus should be seen as the last diagnosis for a patient with oral lichenoid changes.