پاسخ ايمونولوژيك در لنفادنيت از تلقيح واكسن ب .ث .ژ

Immunologic Response in BCG Limphadenitis

Post BCG-adenitis is one of the most common complications of BCG vaccination, however the precise underlying immunologic response has not clarified yet. To determine the immunologic response in these patients, 56 patients with BCG adenitis and 46 healthy infants (as the control group) were enrolled in this study. The age range was between 2 months to 2 years and all cases had been vaccinated with Pasteur strain of BCG at birth. The tuberculin test was performed for both the patients and the control group, using 0.1 ml of PPD-S antigen with Mantoux method. There was a significant difference between the two groups (P<0.001) showing a median in duration of 19.7 mm for patient group versus 8.5 mm for control one . The high degree of delayed hypersensitivity reaction is most likely the cause of necrosis and lymph node enlargement. Apoptosis and imbalance between Th 1 and Th2 responses of T-cell lymphocytes cab be considered as the underlying cause for the results obtained; however the regulatory mechanisms, especially the genetic controlling basis for immunologic response and immune cell analysis is further warranted to find the exact controlling mechanisms for the observed differences. For finding the exact causes of BCG lymphadenitis and Immunologic response in two groups , determination of apoptosis cytokines and Th-cells activity in another study is highly suggested .