بررسي شاخص هاي ايمني هومورال و هورمون تيروييد دوازده سال بعد از مصدوميت با گاز خردل در مصدومين شيميايي جنگ تحميلي

Study of Serum T3, T4, TSH and Humoral Immunity of Patients Exposed to Sulfur Mustard

In this study, we investigated the effects of sulfur mustard on immune and endocrine systems of 90 patients after 12 years of their exposure, and 30 healthy people (all males). The assay of humoral immunity contents (IgG, 1gM. IgA, C3, and C4) was done by SRID method and the measurements of T3 and T4 were carried out by RID, and TSA assay by IRMI. All of the mentioned assays were applied on the three groups of the patients: mild, moderate and severe; and the results were compared with normal population using SPSS program. Our finding about IgG (P=0.001) and serum IgM showed significant variations with elevated values for IgG and little decrease for IgM (P=0.0002). Serum IgA values showed no significant differences between groups (P=0.363). Serum C4 was increased but there wasnot any significant difference in the patients compared with normal group (P=0.0222). Disorder existed in IgG up regulation suppression on native B cell creation in bone marrow. Hyperactivity in the macrophages (complement synthesis) along with auto-antibody phenomena in some tissues may occur because of sulfur mustardʹs destructive effects on humoral immune system. Our survey also show significant variation along with an increase on FT41 (P=0.0001) and FT31 (P=0.00060) as well as TT3 (P=0.0031), while the assay of TT4 decreased with significantly (0.0001). High elevated amount with significant variation were seen in T3 resin uptake (P=0.0134). TSH assays showed a trivial decrease between patients and normal population. Disorders in thyroid hormone secretion were attributed to Euthyroid Sick Syndrome.