بررسي فراواني ناقلين استافيلوكك طلايي در بيني و الگوي مقاومت آنتي بيوتيكي آن در كاركنان مركز آموزشي -درماني رازي قايم شهر پاييز 1382

Nasal carriage and antibiotic resistance of Staphylococcus aureus isolates of Razi hospital personel, Qaemshahr, 1382

Background and purpose: Methicillin resistant Staphylococcus aureus (MRSA) is one of the most important nosocomial pathogen with increasing prevalence in recent three decades worldwide. The most important source of infection is spread through health care worker. This cross sectional study was performed among personell of Razi hospital in a one month period (autum 2003) to determine the perevalence of S.aureus nasal carrier and its antibiotic resistance pattern. Materials and methods: Anterior nasal sampling from healthy personel was done using sterile moistened cotton swab, and the sample inserted into Neutral medium (broth) and transferred to the laberatory for assessing the existence of S.aurens and antibiogram related to seven antibiotics considering the NCCLS criteria. Results: This study revealed that 36% of participants had nasal clonization of S.aureus. Carriage rate of S.aureus and MRSA differed in various professional groups, (about 40% in medical staff and 48% in paramedical staff). The highest rate of resistance was against Oxacillin 83% (the indicator of MRSA) and the lowest was against chloramphenicole (2.8%). Resistance against Vancomycin (VRSA) was seen in 2 cases (5.5%) Conclusion: In this study, carriage prevalence was less than expected but similar to the prevalence in the community (20.40%). Antibiotic resistance was unexpectedly higher than the other studies though. High prevalence of MRSA and specially, existence of VRSA & VISA must be considered very seriously. It can be the result of continious exposure of organisms with various types of antibiotics and unrestricted use of antibiotics in hospitals.