مقايسه اثر استامينوفن خوراكي با دوز Mg/Kg 15 و 10 و استامينوفن ركتال با دوز Mg/Kg 15 در كاهش تب كودكان

COMPARISON OF THE EFFICACY OF ORAL (10 &15 mg/kg)AND RECTAL (15 mg/kg) ACETAMINOPHEN IN FEVER REDUCTION IN CHILDREN

Introduction: Fever is the most common symptom of patients referring to pediatrics clinics.. The first choice for antipyretic medication is acetaminophen with dosage of 10-15 mg/kg every 4-6 hours. We compared the efficacy of oral (I 0 & 15 mg/kg) and recta! (15 mg/kg) acetaminophen in fever reduction in children Methods: A randomized, controlled trial was performed in 90 patients aged between 6months and 6 years with fever > 39" Celsius. The patients were divided into three groups; Group 1 administerd rectal acetaminophen 15mg/kg, (iroup2 oral Acetaminophen 15mg/kg and Group3 oral acetaminophen 10mg/kg. The results at the end of the first and third hour were assessed. Results: The rate of temperature reduction at the end of the first and third hour in the group receiving rectal acetaminophen (15mg/kg) was 1.07 +0.16 and 1174 + 0.25, respectively. The rate of temperature at the end of the first and third hour in the group receiving oral acetaminophen (15mg/kg) was 0.98 + 0.19 and 1.25 and 1.7 0.14, respectively The rate of temperature reduction at the end of the first and third hour in the group receiving oral acetaminophen (10mg/kg) was 0.63 +0.18 and 1.25+ 0.22, respectively Conclusion: There was no significant difference in temperature reduction between the groups receiving oral (I5mg/kg) and rectal acetaminophen, but oral acetaminophen (10 mg/kg) was less effective in temperature reduction.