بررسي اثر بكلوفن در سم زدايي بيماران وابسته به ترياك

Effectiveness of Baclofen in detoxification of opium dependency

Introduction: Results of some studies suggest that Baclofen (a GAB A receptoragonist ) maybe effective in detoxification ofopium dependency. Thus we have done this study in order to identify possible efficacy of Baclofen for detoxification ofopium dependency. Materials& methods: This study is adouble- blind randomized clinical trial. We selected 52 patients with opium dependency and with other criterias that we have designed on the basis of DSM-IV TR. Then we randomly assigned patients to two outpatient groups. The first group received Baclofen (40 mg/day) and second group received placebo fortwoweeks accompanied by similar drugs.These verity of the opium withdrawal symptoms were measured by SOWS ( short opiate withdrawal scale) and two other questionnaires for measuring mental and physical symptoms of opium withdrawal in days of 0, 2, 4, 7 and 14 . Findings: Baclofen group showed a superiority over p lacebo in the management of withdrawal symptoms ofopium dependency, but there was not a significant statistical relationship. Conclusion: Baclofen maybe considered as an effective adjuvant agent in the manage mentofmental and physical symptomsofopi urn withdrawal. Howeverfurtherstudies to confirm our results is warranted.