فاكتور رشد اپي درمال در سرطان پستان و رابطه ي آن با درگيري گره هاي لنفاوي

Background: Breast cancer is the most common type of cancer in females. There are some contraversies about epidermal growth factor and itʹs receptor expression in invasive breast cancer and also itʹs relation with the prognosis of the diseases. So this study was designed to detect the frequency of these receptors in invasive breast cancers and also their relation with lymph node involvement in Isfahan from 2001 to 2002. Methods: This descriptive study was preformed on pathologic samples of 43 patients with invasive primary breast cancer. From the sampling blocks pathologic samples with 6-micron sections were prepared and were stained by Hematoxilin-Eosin for diagnosis of samples and detection of lymph node involvement. Epidermal growth factorsʹ receptors were detected by immunohistochemistry methods. The data were analysed by x2 test. Results: Epidermal Growth Factor Receptors (EGFR) were detected in 16 cases. 12 of 16 cases with these receptors had lymph node involvement. 38 cases suffered from invasive ductal cacinoma and 5 cases had invasive lobular carcinoma. Affected lymph node were detected in 30 samples. There was no relation between EGFRs expression and lymph node involvement as well as cancer type. Conclusion: The study of lymph nodes that carefully removed by a surgeon is more important than immunohistochemical staining in the prognosis of breast cancer.