مقايسه ميزان تخمك گذاري در زنانان نابارور مقاوم به انسولين و حساس به انسولين

Comparison of Anovulation Rate in Infertile Women with Insulin Resistance and Control Group during 2000-2002 at Mashad (Montasarieh) Infertility Center

Background and Objectives:We carried out a prospective study on insulin resistance and its relationship with anovulation from November 2000 to January 2002 in Montaseria Infertility Center. Materials and Methods: We had two groups ofʹ infertile women including insulin resistance and without insulin resistance to study. They were similar in age, monarch age, marriage age and duration of infertility. They had no important history of medical or surgical diseases. Results: Oligomenorrhea was more common in study group than control group (80%vs26.7%), whereas anovulation was common in study group (80% vs 23%). The relationship between two groups was significant. Obesity was more common in study group than control group (80% vs 55.4%), and the average BMI was 32.13 Kglm2 vs 28.9 Kg/m`, but there was no relationship between them. The mean waist to hip ratio (WHIZ) in the insulin resistant patients was greater than control group and the relationship between them was significant. Hisutism was 6.5 times more common in the study group than the other group. Study group flatletʹs had gerater amount of fasting serum insulin level (27.06p.u/ml), greater L11/FSH ratio (2.48 vs 1.48) and lesser amount of serum progestron (2.58 vs 5.9 mg/dl) than control group . The fasting blood sugar was similar in two groups. Conclusion: It is proper to monitor glucose tolerance with periodic glucose tolerance testing in infertile patients with oligomenorrhea, android obesity and hisutism .hl the treatment process it is necessery to get weight loss and excersize as well as adding anti insulin drugs to ovulation induction agents.