كليدواژه :
نوزاد نارس , پزشكي , مجراي شرياني باز , Premature infant , Patent ductus arteriosus
چكيده لاتين :
lntroduction: The advance in survival of premature neonates has significantly increased the incidence of patent ,(ductus arteriosus (PDA). The pharmacological closure of the duct by untiprostoglandins has changed the clinical course of PDA. Early diagnosis and management of PDA can prevent many forseeable complications. The objectives of this study were to determine the incidence, clinical profile and outcome of PDA in premature infants.
Methods: In this study, ,seventeen neonates admitted over a one year period from September 2000 to November 2001 to the NICU at Nemazee hospital of Shiraz University of Medical Sciences, were diagnosed as cases with PDA. The epidemiologic and clinical profile, management and outcome of PDA were investigated by a cross-sectional design. Echocardiography was used to confirm the clinically suspected PDA and repeated to demonstrate the closure of PDA.
Results: PDA occurred in 14.9% of the total 111 premature infants who were admitted to NICTU The analysis revealed that respiratory distress syndrome (RDS) and pneumonia were the most determinant factors- in 12 rases (70.6`%,) card sepsis in 3 (17.6%). More than three-fourth of the neonates had an onset of PDA in the first seek of life accompanied by an inverse relation to birth weight and geslatianal age. The major presenting features were systolic murmur (100%), bounding pulses (30%) and tachycardia (47%). About 1(2.3% (Oho, neonates responded to oral ibuprofen with no complications,
Conclusion: Detection of abnormal heart ,sounds can be the best guide for early diagnosis of PDA especially in premature infants with RDS. Using echocardiography for confirmation of diagnosis and initiation of antiprostaglandins is crucial in preventing any complications in these patients.
