بررسي ويسكوزيته خون و فاكتورهاي مهم مربوطه در بيماران ديابتي با عوارض قلبي عروقي

A STUDY OF VISCOSITY AND RELATED IMPORTANT FACTORS IN DIABETIC PATIENTS WITH CARDIOVASCULAR SYMPTOMS

Background and Objectives: Diabetes mellitus is the most common endocrine disease. It has many implications and the most important is the cardiovascular ones, which are one of the causes of death in diabetic patients. .Blood viscosity is one of the main factors impairing microcirculation and producing microangiopathy. Materials and Methods: In this study 13 male diabetic patients, 43-60 years of age with cardiovascular implications and 10 healthy male subjects in the same age groups were studied as controls.. Whole blood viscosity and plasma viscosity were measured. Other factors such as glucose, fibrinogen, hematocrit, albumin and total protein that can affect viscosity were also measured. Results: Results showed increased total viscosities in the diabetics compared with controls, but only whole blood viscosity showed a significant difference (p<0.01). All factors except albumin were higher in diabetics than in controls, but only glucose and fibrinogen showed statistically significant difference (p<0.001) between diabetics and controls. Albumin level was lower in diabetic group, but not significant . Conclusions: It seems that the main reason for increased viscosity in these cases was change in plasma composition ( high glucose and fibrinogen). It is likely that high glucose and fibrinogen in diabetic patients may increase blood cell aggregation that results in high blood viscosity.