مطالعه اثر اسيد ريينوييك بر تكامل غير طبيعي اندامهاي حركتي موش

Retinoic acid-induced abnormal development of motor limbs in the mouse

In this study, teratogenic effect of retinoic acid, foil wing single dose injection of 200mg/kg of retinoic acid to pregnant balb/c mice of 2 months old on 1 lth-12th days of gestationis investigated. Control group received physiological serum in the same manner and all offetuses (experimental and control) were collected on day 18. Retinoic acid administration in 1 lth postconceptional day resulted in significant malformations in skeletal system and some of limb defects such as asymetry in axial limbs, phochomelia, micromelia, amelia, synductyliand lobster clow among experimental fetuses. These data indicate that a effective dose of retinoic acid in critical periods of development can interfers differentiation and produce motor limbs malformation.