مقايسه تاثير كپسول مفناميك اسيد و زيره بر شدت قاعدگي دردناك اوليه دختران

Comparison of the effect of Mefenaniia acid and earumearvi on the severity ofprimary dysmenorrhea in Mashhad high school students (1999-2000).

Background and purpose: About 50% of women experience primary dysmenorrhea with no evidence- of primary pelvic desease. Current drugs for the treatment of primary dysmenorrhea had contraindication as for mefenamic acid and carumcarvi in primary dysmenrrhea. Materials and Methods: This research was a prospective randomized clinical trial. The cases were 500 high school students (14 - 18 years) with primary dysmenorrhea randomaly allocated into five groups with 100 cases in each group. Group I took one carcumcarvi cap carumcarve bid, Group IV placebo cap tid and, group V one mefenamic acid cap tid. All of these groups were evaluated for 1-3 days in two cycles. Results: There was significant difference in pain relief between placebo group. and other groups: There was a significant difference between group 3 with other groups of carumcarvi and mefenamic acid group , and also between group I and group II and mefenamic acid. Conclusion: the of 2 caps of carumcarvi tid is more effective than the other groups of carumcarvi and there was not significant difference in pain relief between group II and mefenamic acid group.