بررسي سطح استريول بزاق در پيشگويي زايمان زودرس

Evaluation of Salivary Estriol Level in Prediction of Preterm Labor

The purpose of this study was to evaluate of salivary estriol level in hospitalized women with diagnosis preterm labor. This study was prospective study, in which salivary estriol specimens were obtained from 43 women at 24-34 week 6 days gestational age with symptoms of preterm labor (between 9AM and 8 PM). Samples were kept frozen at-20°C. Salivary estriol was assayed by a specific enzyme linked immunoassay. We compared maternal salivary estriol levels between two groups, case group with preterm labor and delivery (22 individuals) and control group with preterm labor and term delivery (21 individuals). The results have showed that the mean ± standard error salivary estriol levels in 31, 32, 33 and 34 weeks gestational in case group were higher than control group. The results showed that the mean ± standard error salivary estriol level in case group (0.31±0.21) was higher than control group (0.25±0.21). Receiver-operator curve analyses showed that exceeding a 18.75 ng/dl saliva estriol level was associated with occurrence of preterm delivery (sensitivity= 68.2% , 57.1% specificity, 62.5% positive predictive value, 63.2% negative predictive value).