تاثير كوتريموكسازول بر رفتارهاي جنسي و تغييرات بافت بيضه در موش هاي صحرايي نر بالغ

The Effect of Co-Trimoxazole on Sexual Behavior and Testicular Tissue Changes in Adult Male Rats

Background: There have been few reports concering the effect of co-trimoxazole on Spermatogensis. However, no reports have been available on the effect of the drug on sexual behavior. The aim of this research was determination of the effect of co-trimoxazole on sexual behavior of adult male rats in 2003. Materials and Methods: In this experimental study 50 withstar rats weighing 200 - 220 gr were selected and divided into 5 groups of ten. Three experimental groups received co-trimoxazole of 30,60 and 120 mg/kg, while the sham group received propylene glycol as solvent. The control group received nothing. The drug was injected subcutaneously for 14 days and during this period the parameters related to sexual behavior were surveyed. At the end of this period histological specimens were prepared and examined by light microscope. Results: The results seem to indicate that there are significant differences among control group and mount latency, intermission latency, post-ejaculatory interval and ejaculatory latency in experimental groups (P<0.05). Mount frequency and intercopulatory interval decreased in experimental groups. Histologic survey of testicles revealed that co-trimoxazole of 120 mg/kg dosage causes a decline in spermatozoa density in seminiferous tubules, and sertoli cells. However, no change was caused in arrangement and number of leydig cells. Conclusions: Based on this research and other reports co-trimoxazole gives rise to a decline in sexual motivation and function. Moreover, co-trimoxazole causes a direct reduction in spermatozoa and sertoli cells.