بررسي تاثير شرايط مختلف نگهداري بر خواص آنتاسيدي قرصهاي هيدروكسد آلومينيم

The effects of various storing conditions on the antacid properties of aluminium hydroxid tablets

Aluminum hydroxide tablets stored under different temperature and relative humidities for 3 months and evaluated neutralizing properties such as acid neutralizing capacity (A.N.C) , neutralizing rate (N.R), duration of neutralizing effect (D.N.E) and onset of neutralizing effect (O.N.E). Among these parameters N.R and O.N.E were affected by the storage condition whereas the D.N.E and A.N.C were not significantly affected. Maximum reduction of N.R was occurred at the highest temperature and relative humidity (45°C, 96.2%). X- Ray diffraction studies on the Aluminum hydroxide powders showed some differences between powders stored at normal condition with those stored under high temperatures and relative humidities. IR-spectroscopy rejected any chemical changes in the stored powders and determined that differences in the neutralizing properties resulted to crystal changes in the powders during storage time.