اثرات سديم فلورايد بر فعاليت آنزيم ترانس آميناز و غلظت پروتيين تام سرم موش صحرايي

Effect of sodium fluoride on serum total protein levels and transaminase activity in rats

Sodium fluoride may effect on the protein metabolism. This study was designed to determine the effects of sodium fluoride on total serum protein and transaminase activity in rats. Transaminase activity and serum total protein level were tested in adult male Spragu-Dawley rats (210-250g) after treating with sodium fluoride at 10-30 mg/kg dose level daily for 90 days. Transaminase activity was measured by determination of NAD at 340 nm by spectrophotometer. Serum total protein was measured by sepctrophotometer at 750 nm. After ingestion of sodium fluoride for 90 days the average serum total protein level of the rats in the treatment group was decreased significantly compared to that in the control group [1.9 +/-0.1 (mean +/-SD,n=140) vs. 3.1+/-0.2] mg/dl. Serum transaminase activity in the treatment group was increased compared to that in the control [5.3 +/- 0.4 (mean+/-SD) ,n=14) vs. micro mol/min/ml. The average total serum protein level of the rats in the treatment group was decreased significantly compared to that in the control, also serum transaminase activity in the treatment group was increased compared to that in the control.