فرمولاسيون فرص گريزوفولوين با استفاده از بتاسيكلودكسترين و سورفكتانت آنيوني

Griseofulvin tablet formulation using p-Cyclodextrin and anionic surfactant

Griseofulvin is a poorly soluble antibiotic drug with an irregular oral absorption. To improve the dissolution rate, chemical stability, absorption and bioavailavility, pharmaceutical modification of drug molecules has been developed by inclusion complexation. Three types of inclusion complexes were prepared by coprecipitation method in various molar ratios of 1:1, 2:1 and 1:2 of the drug and p-cyclodextrin respectively. The inclusion complexes were characterized by dissolution test and IR studies. Sodium lauryl sulfate as an anionic surfactant was used with the concentration of 1, 2 and 3% w/w in the tablet formulations. In vitro drug release studies showed that SLS significantly increased the dissolution rate of griseofulvin. Finally, the effect of the inclusion complex and SLS in the concentration of 3% was determined on the dissolution rate of the drug. Addition of SLS to the formulation containing the complex decreased the dissolution rate of griseofulvin.