تاثير هالوپريدول بر وزن و تكامل اندام هاي جنين موش

The Effect of Haloperidol on the Wieght Loss and Development of Limb Budds in Mouse Embryo

Background and Objectives: Haloperidol, chemically belongs to the group of hutyrophenone derivatives, is used as a sedative drug. This drug interfers with embryo implantation in endometrium and causes malformations such as phocomelia as well as low birth weight. Materials and Methods: To evaluate effects of haloperidol on developing limb builds and weight loss in the mouse embryo, 5-10 mg/kg haloperidol was injected intra-peritoneally to the mice on the Sth gestational day. Thirteen days after gestation, the fetuses were removed from uterine and were examined macroscopically and microscopically. Results: This study revealed that haloperidol can result in weight loss in embryos. The greatest reduction, was observed in embryos located at the either ends of uterus. Delay in growth of limbs, was also observed as outpocketings from the ventrolateral body wall. In microscopic sections, limbs are observed as a mesenchymal axis covered by ectodermal cells. Conclusion: Haloperidol effects are reflected as increased levels of corticosteroids specially glucocorticosteroid, decreased levels of growth hormone and hone formation, and increased absorption of minerals by bones. In addition, the administration of this drug at the primary stages of gestation, should be prevented.