تاثير جايگزيني هورمون ها همراه با كلسيم و ويتامين D در استيوپروز خانم هاي يايسه

The Effect of Hormone Replacement Therapy with Calcium plus Vitamin-D on Osteoporosis in Postmenopausal Women

Postmeopausal esterogen replacement therapy prevents the development of osteoporosis and reduces the risk of fracture . The amount of bone density reduction in in women without this kind of therapy is 3% per year . Resaearch has shown that the bone density of Iranian healthy women is 6.5% in lumbar spine and 5.4% in femoral neck which are quite lower than those of the white women and hence are predisposed to osteopoprosis . This prospective randomized clinical trial involved 100 women (45-55 years old) divided into two groups: group one received 0.625 mg tablet conjugated esterogen and 2.5 medroxy progesterone plus two calcium (500 mg) and vitamin D (200 unit) daily . The subjects were randomly selected by population proportion and were tested for their Routine Hormone Assay and clinical evaluation . Their BMD were estimated by dual energy X-ray absorptometetry (DEXA) for L2-L4 spine and neck of femor before and about a year after the treatment . No significant difference was found to exist in the bone mineral density of L2-L4 spine and neck of the femor in the two groups before the treatment but t-test showed thst there was a significant difference as for the BMD recovery of the groups after the treatment (p<0.0001) . BMD of the subjects treated with HRT had improved but that of the Calcium plus Vitamin-D group had diminshed after a year . Therefore , it is clear that calcium and vitamin D treatment is not sufficient to prevent osteporosis in womern . This study revealed that esterogen replacement therapy (ERT) along with calcium plus Vitamin-D increased BMD in postmenopausal women .