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The Effect of Combination Therapy on Osteoporosis

Osteoporosis is most common osteoporosis causing increased disability and mortality in the elderly. Many medicinal and non-medicinal treatmnels have been suggested for the prevention of the progressive loss of the hones and treatment of the loss of bone mineral density by preventing hone wasting or enhancing hone generation in menopausic women and the elderly. Although single drug treatment is preferred, combination therapy is suggested in most studies. In the present study, combination therapy with alcndronate, calcuim and vitamin D together with regular exercise was prescribed for 66 patients with osteoporosis complication. Bone mineral density (BMD) and T-score were measured before and after therapy in all patients. After treatment for 14.27 +4.7 months, significant increases were observed in BMD by 1.52+4.48, 2.5+4.68 and 2.6+4.17 precent in pelvis, spine and forearm respectively. Significant increases were also observed in T-score of pelvis, spine and forearm by 0.115+0.39, 0.149+0.3 and 1.34+0.5 respectively. Therefore, the efficacy of combination therapy in the treatment of osteoporosis is verified and suggested to he applied ifʹ economic and medical conditions of the patient demand.