تاثير هيپوترمي در تثبيت حافظه در موشهاي سفيد آزمايشگاهي نر

Background and Objectives:The process through which memory is formed and factors affecting it, are among issues under scrutiny in neuroscience. These, however, lack many undiscovered aspects. On the other hand, the wide spectrum of utilization of hypothermia for medical and surgical purposes, raises the question of the effect on memory. Materials and Methods:I n the present study 70 male wistar rats were randomly divided into 7 groups (A-G, 10 rats each). Control group (group A) was trained using "passive avoidance technique" and then the degree of their consolidation of memory was tested 24hours later. This was incorpororated. as basic protocol for other groups. Groups B and C also went under halothane anaesthesia for 15 and 60 minutes respectively immediately after training. These behaved as second line control groups. For the groups left, groups D and F received 15 minutes halothane anaesthesia plus hypothermia, 28±1° C and 24±1° C respectively. Groups E and G were the same as groups D and F but the length of hypothermia was 60 minutes. Results: Results obtained indicated no significant effect of halothane and superficial hypothermia (28+1Oe) for 15min on memory consolidation, but deep hypothermia (24±1°C) for 15 and 60 minutes had significant effects (p<0.05) on memory retrieval. Conclusion: Results suggest that mild hypothermia in a short time has no effects on memory but deep hypothermia at the same time, produces significant effects on memory consolidation.