بررسي اثرات ضد كرم گياه بومادران بر روي انگل اكسيور در موش

Study on antihelminthic effects of Achillea millefolium on oxyuris

Background and purpose: In Iranian traditional medicince in the regions of Azarbayjan and Khorasan Achillea millefolium has been used for treatment of worm infection. Aim of this study is to evaluate the antihelminthic effects of millefolium extract for treatment of the most common intestinal nematode in mouse. Materials and methods. Extraction was done by reflux condenser method, and the essence was prepared through hydrodistilation and given to balbIC mice under study infected experimentally with oxyuris mice under study were divided in three groups based an administration of extract concentrated exatract, and essence as compared with the control group, antihelminthic properties were evalauted by Graham and sauden methods. Results: Extract and essence of the plant caused inactivation of oxyuris, but no effect on the eggs. The results of different concentrations of extract and essence in balb/C mice experimentally infected with oxyuris indicate absolute antihelminthic property(P=0.0001). Effective part of plant was the flower extract having partial ED50 in 20 ml/gram in deciliter. The essence with 0.5 ml/gram in decliter. had the same effect. The first leathal dose(LD) for the flower extract was about 40 mg/deciliter and for essence 102 mg/deciliter. Also the extract and essence caused reduction of eggs excretion in the mice under investigation which have been dose dependent P= 0.0001. Achillea millefolium has absolute anti helminthic property and application of this plant as an antihelminthic, needs more proper studies. Conclusion: Products of this plant particularly extract and essence from the flower had high antihelminthic property.