ارزيابي عوامل خطر و ليپوپروتيين A در زنان قبل از يايسگي با بيماري عروق كرونر

EVALUATION OF THE ROLE OF CORONARY RISK FACTORS AND ʹLIPOPROTEIN (a) IN PREMENOPAUSAL WOMEN WITH CORONARY ARTERY DISEASE

Background and Objectives: An increasing trend in acute coronary events is being observed in premenopausal young women who are admitted in coronary care unit. With respect to above phenomenon, we decided to evaluate these patients prospectively in a cohort study , considering serum lipoprotein (a) [LP(a)] level and coronary risk factors. Materials and Methods: Out of 79 cases studied, 62 belonged to patient group and 17 cases were taken as controls. Sixty one of the total cases underwent coronary angiography. Results: From the patient group, forty six cases (75%) had LP(a) level of > 30 mg/dl and 16 (25%) had LP(a) level of <30 mgldl as compared to the control group, which is a significant difference (p=0.033). Thirty nine cases from patient group were admitted with acute myocardial infarction, 30 of them had LP(a) level of >30 mg/dl , and 9 had < 30 mg/dl, difference being statistically significant (p=0.04). Those patients who were admitted with thromboembolic events such as pulmonary emboli, cerebral emboli and occlusion of bypass graft vessels (4 cases) had LP(a) level of > 60 mg/di, however this phenomenon was not observed in those cases with LP(a) level of <60 mgldl. Conclusion: It can be concluded that there is a good correlation between abnormal elevated lipoprotein (a) and coronary artery disease in premenopausal women.