گزارش دو مورد لوسمي حاد غير لنفوسيتيك زودهنگام ، متعاقب شيمي درماني

A REPORT OF TWO CASES WITH EARLY SECONDARY ACUTE NON LYMPHOCYTIC LEUKEMIA (ANLL) AFTER CHEMOTHERAPY

Long term treatments are gaining more attention now a days with due attention to successful treatment associated with malignancy and survival of patient for a longer time. However, one of the incidental feature appearing during such treatment is secondary malignancy. In this report two cases are presented, aged 55 and 18 years, with breast cancer and abdominal large cell lymphoma respectively who were treated with CAP (Cyclophosphamide - Adriamycin - 5-Fluorouracil) and CHOP (Cyclophosphamide - Hydroxydaunorubicin -Oncovin - Prednisone) chemotherapy. Both the patients developed ANLL 11 and 18 months after treatment respectively. They were given 6 grams of cyclophosphamide and were followed up for 2 years. Since threshold level of cyclophosphamide induced leukemia is less than twenty grams, therefore interference of other factors such as cytogenetic abnormalities seems amenable.