بررسي تغييرات بافت شناسي معده در موش صحرايي با ديابت مزمن و معتاد به مورفين

Survey of Stomach Histological Changes in Chronic Diabetic Rat Addict to Mmorphin

Diabetic gasteroparalysis is a kind of motor electromechanical disoder in which gaster and other portion of GI system is motionless . In this research , we examined effects of morphine addiction on diabetic gastroparalysis . We divided the 30 female N-MARL rat in 4 groups . In normal groups , all rats recieved satin (volume / kg) . In the diabetic group , all rats received STZ (45 mg/kg) ; in normal addict group , rats recieved morphine 3()-50 mg/kg for four sequential days and twice a day . In the fourth group , rats recived first STZ (45mg/kg) Sc and then morphine (30-50mg/kg Sc) _ For addiction test , withdrawal syndrom was evaluated . Gastroparalysis is studied by macroscopical and microscopical slice . Slices stained by H&E and triehrom mason . We found that gastric morphology in diabetic rats is larger than normal rats ; in addition , gastric morphology in diabetic rats is larger than normal rats ; fundus in diabetic rats was of less folding . The thickness of extrnal muscular layer in diabetic rats is thinner but its histological structure is not changed ; pylor sphincter in diabetic rats was hyperthrophized . In addict diabetic rats , only epithelial layer grew and folded and gaster volume in addict diabetic rats was less increased (1ʹ0.05) . These results indicaeted that addiction improved the gasteroparalysis in diabetic rats .