تعيين مقادير سرمي هموسيستئين و هيپرهموسيستئينمي در شمال خليج فارس‌

Assessment of serum Homocysteine (level and hyperhomocysteinaemia in the northern (Persian Cjutf

Background: Homocysteine is a non essential amino acid which is deri\ed from metabolism of the essential amino acid, metionin. It has been shown that an elevated serum homocysteine level in adults is associated with vascular diseases. In this study, we determined serum homocysteine level and its gender and age distribution m three cities of Bushehr. Gena\eh and Deilam in the northern Persian Gulf. Methods: A total of 1699 inhabitants of the north region of the Persian Gulf were selected based on a multi stage stratified clustered sampling and a fasting blood sample was taken from them. We measured serum homocysteine level usmg en/yme immuno assay method with accuracy limit of 1 pmol/L. I lyperhomocyteinaemia was defined as homocysteine more than 14 jumol/L, Results: Mean plasma homocysteine level was 14.63±7.08 pmol/L (17.72-i6.63 umol/L lor men and 12.73±6.78 |umol/L for women). No correlation between homocysteine and age was found. The prevalence of hyperhomocysteinaemia was 51.2% (22.2% in male and 2()% in female). Conclusion: The homocysteine level in the north region of the Persian Gulf genet a I population is high. Further study is essential to reveal the reason of the high homocysteine serum le\el in the inhabitants of the northern Persian Gulf with emphasis on folic acid and \ itamin B12 serum lex els.