تاثير متفاوت تستوسترون بر درد حاد و مزمن در موش‌هاي صحرايي نر گنادكتومي شده‌

Different Effects of Testosterone on Acute and Chronic Pain inGonadectomized Male Rats

Introduction & Objective: Nociception and behavioral responses to noxious stimuli are different in males and females. It seems that these differences are due to the effects 01 sex hormones on fhe pain mechanisms The aim of the current study was to evaluate the effect of testosterone administration on nociception by formalin test in gonadectomized rats. Material & Methods: In this study 32 male wistar rats were divided Into four groups (n=8); the control rats without receiving any drug or surgical operation, the sham - operated animals with surgical stress, the gonadectomized rats receiving 0,5 ml vehicle (olive oil) i.p, and the gonadectomized rats receiving testosterone enantate (6 mg/l00 gr body weight in 05 ml vehicle i.p.). On the sixth day after gonadectomy operation, formalin test was done in all rats. Pain scores in formalin test were statistically analyzed by SPSS and ANOVA. Results: The results showed that testosterone caused an increase in pain score in acute phase of formalin test in gonadectomized rats compared with sham-operated group (p