تاثير اسيدهاي چرب امگا - 3 برسطح سرمي هموسيستيين و مالدن‌دي‌آلدهيد در بيماران ديابتي نوع 2

Level and 2 Effects of ro3 on Serum of Malondialdehyde Homocysteine in Type Diabetic Patients

Introduction & Objective: Diabetes is regarded as a serious condition lor both the individual and the society. One of the most important mortality reasons in diabetic patients is atherosclerosis. Many epidemiological studies have shown that the total homocysteine concentration is a risk indicator for cardiovascular disease. Malondialdehyde (MDA) also is a highly toxic by- product formed in part by lipid oxidation derived free radicals. Many studies have shown that its concentration increases considerably in diabetes mellitus. Epidemiological data indicate that the consumption of omega-3 unsaturated latty acids (03FA) leads to a reduction in cardiovascular disorders may protect against metabolic diseases. In recent years, numerous researches on omega-3 fatty acids have been done but it cannot be used as a confident additive. Sa in order to evaluate and compare Ihe effects of w3 on malondialdehyde (as fat peroxidation indicator) and homocysteine on diabetic type 2 patients, this research was carried out in Tehran University. Materials & Methods: A randomized double blind placebo controlled clinical trial was conducted on 81 type 2 diabetic patients, 45--B5 years old with diabetes lor at least 2 years. Diabetic patients were randomly assigned to one of the case or control groups, each subject received 3 capsules per day of omega-3 or placebo for a period of 2 months. 10 ml blood was collected tram each subject at the beginning and al Ihe end 01 a 2-month trial. Serum MDA was delermined with Tlobarbtturic acid for more sensinvity and hornosystein was measured by Hitachi autoanalyzer with Enzymatic Cycling method. Nutrients intakes were estimated using 24 h dietary recall questionnaire at the beginning and at Ihe end at the 2-month trial lor 2 days and analyzed by FPn. T-test also was used to compare groups. Results: Copmaring the mean±S.D 01 BMI and load intake in both groups showed no significanl differences. MDA level degreased 0.72 nmollml in case group but the difference with the control group was not significant but the differences of homosystein level in case (3.1O~mol/llt) and control (O.126~mol!lit) groups were significant Conclusion: Consumption at omega-3 fatty acids supplementation (3 griper day) in capsul form can decrease the serum level of homocysteine in diabetic patients without inducing any changes in MDA level and lipid peroxidation.