رهايش پروژسترون از الستيك سيليكون شبكه‌اي شده با پرتو الكتروني و بررسي خواص مكانيكي آن‌

Progesterone Release from Electron Beam Crosslinked Silicone Rubber and Study of its Mechanical Properties

Modification of the mechanical properties of silico ne rubber were considered for drug delivery systems by using high-energy electron beam (E-beam). In this research work, two diffe rent medical grades of silicone ru bbers were used to prepare matrices containi ng lOwt% progesterone with 2 mm thickne ss and irradiated with E-beam at dose range of 25 up to 200 kGy. Then, the mechanical properties as well as in vitro drug relea se from matrices were investigated. It was observed that the mechanical propert ies of matric es increased initially as a function of irradiation dose due to increasing cross link density and reduction of the molecul ar weight between the cross links and eve ntually they were leveled off. Also. there was no significan t difference in the progesterone release by increasing the irradiation dose. Progesterone crys tal modification was not observed durin g E-beam crosslinking process