اكسيدازها و مقاومت به حشره كش هاي پيرتروييد در حشرات مهم پزشكي

Mixed function oxidases and insecticide resistance in medically important insects

MFOs are a large diverse superfamily of enzymes found in all insect tissues. They are involved in the metabolism of xenobiotics (e.g. drugs, pesticides and plant toxins) and endogenous compounds (e.g. ecdysteroids and juvenile hormones). They are also involved in bioactivation of phosphorothioate compounds such as organophosphorus insecticides. They have very diverse activities like hydroxylation, epoxidation, N-, 0-or S-dealkylation, deamination, sulfoxidation, desulfuration and oxidative dehalogenation. Their diverse functions are achieved through diversity in structure. There are over 100 P450 genes in the Drosophila genome, usually arranged in family clusters. MFO-mediated insecticide metabolism is a common mechanism by which insects become resistant to insecticides. In this mini review article the role of oxidases in insecticide resistance is briefly discussed.