بررسي خاصيت ضدهرپسي عصاره ريشه گياه جعفري مكزيكي عليه ويروس هاي هرپس سيمپلكس تيپ يك و دو انساني در كشت سلول

Evaluation of effects of root extract from Tagetes minuta against human herpes simplex virus type 1 and 2.

Introduction: Nowadays, the attention of researchers has been focused on natural medicine in order to avoid the detrimental side effects of chemical drugs. In this study we assessed the effect of root extract of Tagetes minuta against HSV-1 and HSV-2. Materials and Methods: This research is an experimental study. Root extract of Tagetes minuta was obtained with 70% ethanol by maceration. Vero cells were grown in DMEM containing 5% fetal bovine serum Serial dilutions of extracted suspension (Vio, V2o, V40, ^80, V160) were incubated by the exact titer of viruses and monitored for antiviral activity of extract. Data was analyzed using Doncan test. Results: Root extract obtained from Tagetes minuta significantly has antiviral activity against HSV-1 and HSV-2. This extract has more effect on HSV-2 than HSV-1. This study indicates that antiviral activity of the extract varies between different concentrations and the optimum antiviral activity on both viruses was obtained using Vio concentration. Conclusion:The results of this investigation showed that root extract of Tagetes minuta have good antiviral potenoial against HSV-1 and HSV-2, a good source of drug for treatment of diseases due to HSV-1 and HSV-2.