حساسيت و ويژگي سيتولوژي ادراري در غربالگري تومورهاي اروتليوم افراد مبتلا به هماتوري

Specificity and Sensitivity of Urine Cytology for Screening Patients with Urothelial Tumors and Hematuria

Background and Objectives: The assessment of urinary cytology is helpful in numerous clinical conditions, particularly the test is valuable for screening of patients with high risk for urothelial malignancy and is sufficient for patient follow-up as well as control of any residual of tumor. Materials and Methods: In this investigation urine (midstream) samples were collected from 900 patients with hematuria. Urine was quickly centrifuged, smears were prepared and stained with Papaniculao and Right staining method. Smears were reported on the basis of background, cells types and other sedimentary elements. Sensitivity, specificity and predictive values along with efficacy of this screening method as compared to other tests like cystoscopy and biopsy of tumor were calculated. Results: We observed from the study performed that sensitivity of urine cytology for diagnosis of tumor of bladder was approximately 73.87% and specificity of 99.18%, with positive and negative predictive values being 84.78% and 98.36% respectively. Efficacy of this screening test was found to be 97.67%. Conclusion: Urinary cytology can be used as a valuable screening test in the patients with hematuria, as well as for diagnosis of urothelial tumors due to multiple preferences for example: non invasiveness, high sensitivity, specificity and efficacy to the other tests. This test is suggested as a necessity in screening the high risk population.