اثر كلسترول و لواستاتين بر يادگيري فضايي موش صحرايي نر

EFFECT OF CHOLESTEROL AND LOVASTATIN ON SPATIAL LEARNING IN RAT

In this study the effect of cholestrol and lovastation on spatial learning task, was investigated by using T-maze in male N-MARL rats. The animals were divided into four groups; the first group were fed with diets containing %5 cholesterol at libitum for 7 days, and second group were fed with Lovastation (30mg/kg/day) for 9 days after administration of %5 cholestrol for 7 days, and the third group only were received lovastation (30mg/kg) for 9 days. The fourth group as a control were fed with lab chow diet. The results showed that administration of dietary cholestrol for one week decreased spatial learning (P< 0.05) in comparison with control group. On the other hand, the rats fed with lovastation increased spatial learning task (P< 0.05). The facilitative effect of lovastation prior to training may be due to decreasing of cholestrol. It is assumed that cholestrol produces learning defect, probably by decrease fluidity of membranee, influence on activity of neurotransmitter receptors, ionic channel and also learning activities.