بررسي نتايج استفاده از غلظت كم ميتومايسين - C در عمل فيلترينگ بيماران مبتلا به گلوكوم زاويه باز

Study of Initial Trabeculectomy with Intraoperative Mitomycin-C Application in Primary Open Angle Glaucoma

Background and Objectives: Trabeculectomy is a common surgical procedure that removes part of the trabeculum in the eye to relieve pressure caused by glaucoma. Mitomycin-C (MMC) assisted trabeculectomy has been reported more successful treatment in patients with advanced primary open angle glaucoma. The application of antiproliferative drugs such as MMC in various concentrations and contact time during surgical procedure has been published in various research studies. Materials and Methods: In this study patients received 0.1 mg/ml MMC with 3 minute contact time. Surgery was done in all of the 10 eyes with the same surgeon and surgical technique. After surgery patients were followed up at least for 6 months. Results: During follow-up period, none of the patients had high intraocular pressure (IOP). Complications were as the following: Retinal hemorrhage in 1 case (10%), severe choroidal detachment in 1 case (10%), persistent hypotony and progression of cataract in 4 cases (40%) and mild choroidal effusion in 2 cases (20%). Conclusion: Intraoperative MMC application may increase the success rate of glaucoma surgery but close follow up and meticulous management of the patients are required, specially in the early postoperative period.