ارزيابي نتايج PPD بعد از واكسيناسيون BCG و رابطه آن با اسكار حاصل از اين واكسن در شيرخواران استان كرمانشاه

Evaluation of PPD test Results after BCG Vaccination in Neonates of Kermanshah Province

Background and Objectives: Considering t!ic BCG vaccination in neonatal period, a prospective studs was done with following purposes: Result of PPD test after BCG vaccination in neonatal period, its comparison in breast and non-breast fed infants, e\aluation of the size of BCG vaccination scar, if there is any relationship between the size of scar and PPD test and finally observing how main of these infants develop BCG adenites. Materials and Methods: To fullfill the above objectives 150 neonates (87maies and 63 females) born in Kermanshah province and who received BCG vaccine by an expert technician alter birth, at 3 months of age, were enrolled in the stud}. PPD test was done b\ 0.1 ml of 5 units tuberculin solution made by Razi Institute. Results: Of the total neonates studied, 146 in I ants (97.33%) were found to have BCG scar, the mean size of scar being 5.28±1.56 mm, and there was no significant difference between bovs and girls (p>0.05). After 72 hours Mantoux test results showed mean size of 5.1+3.25 mm. In 68 infants (45.33%) the size of scar after Mantoux test was less than 5 mm.70 infants (46.66%) had between 5-9 mm .1 1 infants (7.33%) had 10-14mm and only one case (0.66%) had 15mm. There was no meaningful difference between males and females(p>0.05). Among those infants who did not had BCG sear, except in one case, others were negative for PPD test, while in infants who had BCG scar but the Mantoux test was negative, the mean size of scar was 4.42--3.72mm. Those infants who had Mantoux test more than 5mm , the mean size of the scar was 5.85 ~3 .3mm. 1 here was a direct relationship between the size of scar and Mantoux test (p<0.05). There was no statistically significant difference regarding the Mantoux test and BCG scar size between breast and non-breast fed infants (p>0.05). Axillary adenites were noticed in 5.33% of the infants. Conclusion: The present study shows that 97% of neonates who are vaccinated after 3 months of birth later develop BCG scar and they have increased immunity against tuberculosis. Secondly, the diagnosis of the tuberculosis on the basis of Mantoux test (more than 10 mm) in vaccinated infants is not absolute and thus, other complementary tests are required.