مطالعه تغييرات غلظت پارامترهاي مربوط به متابوليسم آهن در بيماران ديابتي متعاقب هيپرگليسمي

Evalvation of Parameters Related to Iron Metabolism in Diabetes Mellitus Patients

Background and Objectives: Diabetes mellitus is a disease with multiclinical features caused by relative or absolute insufficiency of insulin secretion. Hyperglycemia, hyperlipidemia and disorder in protein metabolism have been reported in these patients. In addition, there may be non enzymatic glycosylation of hemoglobin and lipid peroxidation. Secretion of pancreatic hormones might be effected by trace elements. The major aim of this study was to investigate changes in parameters related to iron metabolism. Materials and Methods: The study was carried out in 100 males and the same number of female diabetic patients referred to Isfahan Diabetic Center. These patients were classified according to their fasting blood glucose (FBS) into three groups: first group with FBS within the range of the 140-190 mg/dl, second group with FBS ranging from 190-250 mg/dl and third group with FBS higher than 250 mg/di. Female patients were divided as follows: first group with FBS within the range of 130-180 mg/dl, second group with FBS ranging from 180-250 mg/dl and the last group having FBS more than 250 mg/dl. Hemoglobin was measured by cyanomethemoglobin, Iron and TIBC by Iron rapid test, ceruloplasmin by ferroxidase activity using paraphenylendiarnine-hydrochloride as substrate and copper by atomic absorption spectrophotometry. Results: Plasma iron concentration was increased by 8.9, 13.8 and 17.8% respectively in the three groups of female patients and in male groups by 7.3, 14.5 and 17.6% respectively as compared to controls. TIBC was elevated in both the cases. Serum copper level in female groups was elevated by 10.2, 16.5 and 19.1% and in male patients by 11.2, 17.2 and 20.4% respectively. Serum ceruloplasmin level in female patients was elevated by 16.5, 22 and 26.8% and in male by 13, 21 and 25% respectively. There was a positive correlation between copper and ceruloplasmin (r=0.89). Conclusion: It can be concluded that serum parameters related to iron metabolism could be disturbed in patients with high serum level of glucose and thus, these parameters should be monitored regularly in these patients.