اثر ويتامين E در پيشگيري از آثار نامطلوب كادميوم كلرايد در كبد و كليه موش صحرائي

The preventive effect of vitamin E on cadmium chloride-induced toxicity in rat liver and kidney

terrestrial and aquatic ecosystem. Increasing evidence indicated that Cd induced toxicity in human and animals. However, The mechanism by which its produced toxicity is not completely understood. It has been shown that lipid peroxidation is involved in Cd- related toxicity. Vitamin E is an effective antioxidant and free radical scavenger. The aim of this study is to investigate the preventive effect of vitamin E on cadmium-induced toxicity in rat liver and kidney. Materials and Methods:Adult NMARI male rats were treated with 5mg/kg vitamin E or corn oil (vehicle) only. 30 min later animals were given Cd CI2 (ip) at doses of 0.5, 1, 1.5 and 2 mg/kg. The control group received normal saline (vehicle). All animals were treated for 7 consecutive days. 24 hr after last administration all rats were killed with over dose of sodium pentobarbital. The blood was collected for determinations of ALT, AST, ALP, BUN and creatinine. The liver and kidney tissues were removed, fixed and processed for light microscopy, using H&E staining method. CdCk induced dose-dependent injury in both liver and kidney tissues. Results: Statistical analysis showed significant increase all biochemical parameters in CdCfe- treated rats when compared to control groups (p>0.05). Vitamin E had no effect on rat liver or kidney. However, this agent protected cells against CdCk toxicity. Conclusion: The results of this study support the view that vitamin E has potential to protect rat liver and kidney tissues against CdCl2 toxicity.