ارتباط پلي مورفيسم قابل شناسايي توسط آنزيم Bsm I در ژن گيرنده ويتامين D با بيماري مولتيپل اسكلروز در جنوب ايران

The Association of Vitamin D Receptor Gene BsmI Polymorphism with Multiple Sclerosis in Iranian Patients

Background & Aims: 1,25-dihydroxyvitamin D, (1,25 (OHh D3), the biologically active form of vitamin D, exerts an immunosuppressive effect through binding to its specific nuclear receptor. The present case-control study was done to examine the possible association of Bsml polymorphism in vitamin D receptor gene (VOR gene) with severity of multiple sclerosis (MS). Methods: 267 Iranian patients with MS and 292 ethnically and sex matched controls were included in this study. Bsml polymorphism in VOR gene was assessed by PCR-RFLP method. Results: No differences in the allelic distribution were observed in the patients as compared to the controls. Also no difference in genotype distribution of VOR-Bsml polymorphism was observed between patients and controls (p=0.43). Conclusion: Considering the significance of vitamin D, as an immune system regulator and its inhibitory effects on MS, investigation on other VDR gene polymorph isms is recommended.