نقش حفاظتي كلريدليتيوم در مقابل القاي آپوپتوزيس در سلول هاي بنيادي مزانشيمي مشتق از مغز استخوان موش صحرايي در محيط كشت

Protective role of lithium chloride against induced apoptosis in mesenchymal stem cells derived from rat marrow at the culture

AIMS. Abnormalities of the modulatory roles of endothelium and smooth muscles may be initiating factors of diabetic vascular disease. In this study, Effects of chronic exercise training and detraining on cutaneous microvascular responses in streptozotocin-induced diabetic and normal rats and also its effect on LArgininiNitric Oxide pathway are investigated. METHODS. SO male wistar rats (220±10 g) were made diabetic by streptozotocin (60mg/kg, s.c). After I week of diabetes induction, animals were submitted to exercise training for 10 weeks on treadmill and then some of them detrained for 8 weeks. Laser Doppler flowmetery technique used to characterize cutaneous microvascular responses. RESULTS. Ach- induced cutaneous perfusion were increased significantly by training and attenuated by detraining and L-NNA in diabetic groups. Cutaneous microvascular responses to SNP did not alter in control and diabetic by training but decreased significantly by detraining in diabetic rats. Local microinjccuon ofL. Arginin increased cutaneous blood flow in diabetic and normal rats. However this effect augmented by training in diabetic compared to age-matched normal rats. CONCLUSION. Chronic exercise improves endothelium-dependent dilatation and potentiate L-arginin/ NO pathway activity in diabetic rats.