اثر N - استيل سيستئين بر كيفيت زندگي معتادان به مورفين در حال ترك: مطالعه پايلوت

N-acetyl cysteine effect on life quality of morphine addicts in treatment period: A pilote study

AIMS. The purpose of this study is to determine N-acetyl cysteine effect on life quality of addicts who are in treatment period camparing with placebo. METHODS. In this double blind. placebo control clinical trial study, two groups (drug and placebo; each 20 people) among the persons who respect for treatment of their opium addiction in treatment center in Tehran were selected with systematic sampling method. 1200 mg/day drug and placebo were administered to drug and placebo groups, respectively, for 45 days. Quality of life was evaluated with SF-36 standard questionnaire, before and after drug administration. Finally, the results were analyzed with Mann-Whitney and Wilcoxon tests and SPSS software. RESVLTS. SF-36 total point mean, before intervention was 44± 1I in drug group and 40±9 in placebo group that there was no significant relation before intervention (p>0.05). After intervention, SF-36 total point mean in drug and placebo groups were 78±7 and 70±9, respectively, that there was significant relation after intervention between SF-36 total point in Mann-Withney test (p=O.018). CONCLUSION. N-acetyl cysteine has significant effect on improving of life quality in addicts in their addiction treatment period.