اثر لواميزول هيدروكلرايد روي تغييرات لنفوسيتي وعيار آنتي بادي سرمي ضد ويروس نيوكاسل درجوجه هاي گوشتي

The effect of Levamisol hydrochloride on the lymphocyte changes and titer of serum antibody against Newcastle disease virus in broilers chickens

Vaccination at proper time is one of the main strategies to control Newcastle disease. The value of each vaccine depends on the level of antibody production after vaccination. The Levamisol hydrochloride seems to stimulate immune response after vaccination. In this study 225 one day old broiler chickens are di vided into 5 groups and each group is separated in 3 repeat. Group I is considered as control group (without drug administration). Group 2 received Levamisol hydrochloride 2mg/kg subcutaneously in the first day and this was repeated weekly for 6 weeks. Group 3 received IOmg/kg Levamisol hydrochloride each day orally from the first day for 6 weeks. Group 4 received levamisole hydrochloride 2mg/kg simultaneously with vaccine of Newcastle disease subcutaneously. Group 5 received IOmglkg Levamisol hydrochloride orally after being vaccinated for 24 hours. Sampling was carried out 11 days after vaccination. The result shows that there is a significant difference in mean of antibody titer against ND virus and number of the blood lymphocytes between experimental and control group in stage 1 and 2 of vaccination, but there are no significant differences in stage 3 of vaccination. Administration of Levamisol hydrochloride did not influence feed conversion rate and the mean of body weight in any week of growing period. Therefore, it seems that administrating levamisole hydrochloride after vaccination can stimulate immune response to vaccine. However, using levamisole hydrochloride could help immunity system to produce antibody in the primary age.