تعيين فراواني و ميزان حساسيت آنتي بيوتيكي باكتري هاي جدا شده از كشت هاي ادرار، مدفوع و خون ارسالي به آزمايشگاه هاي دانشگاه علوم پزشكي رفسنجان

Frequency and Antimicrobial Susceptibility of Bacteria Isolated from Urine, Stool, and Blood Cultures of Rafsanjan University of Medical Sciences Laboratories During 2003

Background and Objectives: Antimicrobial susceptibility pattern of bacterial agents isolated from clinical samples in different parts of the country provides essential information regarding the selection of antibiotics for all patients living in different areas. Unfortunately data about the frequency and also antimicrobial resistance pattern of phathogen agents in clinical samples is rare in Iran. The aim of this study was to determine the frequency of isolated bacteria collected from urine, stool and peripheral blood and their antimicrobial susceptibility profiles in Rafsanjan city during year 2003. Materials and Methods: In this descriptive study, a total of 8247 clinical samples were analysed. Specimens were cultured and disk diffusion susceptibility testing were performed according to National Committee of Clinical Laboratory Standard (NCCLS) guideline. Results: The most common bacteria isolated from stool, urine and blood specimens were shigella, E.coli, and coagulase negative staphylococcus, respectively. The urine bacteria were mostly sensitive to ciprofloxacin and cefotaxime. Cefotaxime was also the first choice for E.coli. The stool infections were sensitive to ciprofloxacin, ceftriaxone, and nalidixic acid. These antibiotics and cephalotin were effective agianst shigella. Blood bacteria were sensitive to ciprofloxacin, novobiocin, chloramphenicol, and amikacin. Novobiocin was the only antibiotic effective againts coagulase negative staphylococcus. Conclusion: The rate of antibiotic resistance is increasing in pathogenic bacteria. Based on findings of this study, ciprofloxacin is probably the most effective antibiotic against both Urinnary Truct Infection (UTI) and infectious diarrhea.