تاثير شستشوي برش جراحي با آنتي بيوتيك در پيشگيري از بروز عفونت محل جراحي

The effect of antibiotic irrigation of surgical Incisions in prevention of Surgical Site Infection

Background: surgical site infe ction is one of the most common post operative complications alongside with seps is, card iovascular, pulmonary and thromboembolic complica tions. The development of surgical site infecti on is related to three factors: the degree of microbial contamin ation of the wound during surgery, the duration of the procedure, and host factor s such as diabetes, malnutrition, obesity, immune suppression, and a number of other underlying disease sta tes. Th e purpose of this study was to evaluate the effec ts of topical cephazolin in controlling infection of the site of surgery after non-laparoscop ic cholecystecomy. Methods: One hundred and two of patients referred to the outpatient clinic of Imam Khorneini Hospital from fall 2005 to faJl 2006 non- laparoscopic cholecystectomy enrolled in a random ized clini cal trial. All pat ients underwent the same procedure of ane sthesia and sur gery and they were randomly assigned into two groups of cas es with irrig ation of the site of surgery with I g of topic al Cephazolin pri or to the termination of the operation- and controls. Cephazolin is a first generation cephalosporin which bind s penicillin binding protein and is a potent cell wall synthesis inhibitor. The pati ent s were followed up for six weeks for symptoms and signs of infection including discharge of the wound ; and presen ce of pain, warmness, swe lling and erythema of the wound. Results: There were no s ignificant di fferen ces betw een two study groups regarding mean age, duration of operation, and sex . There was no significant difference in the incidence of infecti on of the site of sur gery (11.8% in both groups with p=O.99) between two groups. Conclusion: Anal yzing the collec ted data confirms that prophylactic use of topi cal cephazolin was unable to decrease the risk of infection of the site of surgery in patients undergoing non - lapa rascop ic cheolecysteetomy.