تهيه ميكروامولسيون روغن تخم كدوي كاغذي(Cucurbita pepo) به عنوان يك حامل داروسازي خوراكي

Microemulsion Preparation from Pumpkin Seed Oil (Cucurbita pepo) as an Oral Drug Carrier

Background: One of the modern Drug Delivery methods is the use of microemulsion for oral delivery of insoluble drugs .To use medicinal plants oil in these systems resulted in therapeutic solution for carrying lipophilic drugs. Pumpkin seed oil is one of the plant oils with high therapeutic properties especially in BPH treatment .The oil has significant absorption in the body. Objective: Microemulsion Preparation from Pumpkin Seed Oil for Oral Drug Delivery Methods: -To choose surfactants and cosurfactants based on oil components structure -To formulate the ingredients with different methods in different conditions -To study the repeatability and stability of samples -To measure particle size Result: Short chained alcohols are not suitable cosurfactants for this research. The best result is obtained with polysorbate 80 as a surfactant and sugar as a cosurfactant. Addition of polymer has no effect on the stability of microemulsion. On the other hand, stirring has no effect in bench scale. It would be better to conduct the experiments at room temperature. Conclusions: Pumpkin oil O/W microemulsion contained 5-10 % oil could be prepared by polysorbate 80 as a surfactant and sugar as a cosurfactant.