بررسي اثر عصاره آبي سير بر يافته هاي باليني خرگوش هاي آلوده به سالمونلا تيف يموريوم

The effect of aqueous garlic extract on clinical manifestations in Salmonella typhimorium infected rabbits

One of the most important intestinals, especially in developing countries is Salmonella infection. Today, antimicrobial resistance is increased and we need new antimicrobial drugs. One of these drugs is herbal drugs. The effects of garlic extract on Salmonella typhimurium infection were studied. 60 Dutch-polish rabbits were divided in 3 equal groups. The rabbits inoculated with 1011 colony forming unit orally. After 48 hours, two groups treated with 20 mg/kg and 40 mg/kg aqueous garlic extracts three times a day. Clinical manifestations are heart rate, weight, temperature and bowel habitus were evaluated after 24, 48, 72, 96 and 168 hours after treatment and at similar times in untreated group. Heart rate, temperature and bowel habitus status were significantly different in 3 groups and different days (p=0.000). Weight did not change significantly (p>0.05). Garlic extract decreased clinical manifestations in salmonella typhimurium infected rabbits. As a result, clinical trials for further studies.